ICECUBE是一种用于检测1 GEV和1 PEV之间大气和天体中微子的光学传感器的立方公斤阵列，该阵列已部署1.45 km至2.45 km的南极的冰盖表面以下1.45 km至2.45 km。来自ICE探测器的事件的分类和重建在ICeCube数据分析中起着核心作用。重建和分类事件是一个挑战，这是由于探测器的几何形状，不均匀的散射和冰中光的吸收，并且低于100 GEV的光，每个事件产生的信号光子数量相对较少。为了应对这一挑战，可以将ICECUBE事件表示为点云图形，并将图形神经网络（GNN）作为分类和重建方法。 GNN能够将中微子事件与宇宙射线背景区分开，对不同的中微子事件类型进行分类，并重建沉积的能量，方向和相互作用顶点。基于仿真，我们提供了1-100 GEV能量范围的比较与当前ICECUBE分析中使用的当前最新最大似然技术，包括已知系统不确定性的影响。对于中微子事件分类，与当前的IceCube方法相比，GNN以固定的假阳性速率（FPR）提高了信号效率的18％。另外，GNN在固定信号效率下将FPR的降低超过8（低于半百分比）。对于能源，方向和相互作用顶点的重建，与当前最大似然技术相比，分辨率平均提高了13％-20％。当在GPU上运行时，GNN能够以几乎是2.7 kHz的中位数ICECUBE触发速率的速率处理ICECUBE事件，这打开了在在线搜索瞬态事件中使用低能量中微子的可能性。

路径计划是设计机器人行为的关键算法方法。基于抽样的方法，例如快速探索随机树（RRT）或概率路线图，是针对路径计划问题的突出算法解决方案。尽管其指数收敛速率，RRT只能找到次优路径。另一方面，$ \ textrm {rrt}^*$是RRT广泛​​使用的扩展名，保证了寻找最佳路径的概率完整性，但在复杂环境中缓慢收敛而在实践中遭受痛苦。此外，现实世界中的机器人环境通常是可观察到的，或者描述的动力学不好，施放了$ \ textrm {rrt}^*$在复杂任务中的应用。本文研究了用于机器人路径计划的流行蒙特卡洛树搜索（MCTS）算法的新型算法公式。值得注意的是，我们通过分析和证明其指数的收敛速率（MCPP）在完全可观察到的马尔可夫决策过程（MDP）的一部分中，并证明其指数收敛速率，而另一部分则是其概率的完整性假设有限的距离可观察性（证明草图），在部分可观察的MDP（POMDP）中找到可行的路径。我们的算法贡献使我们能够采用最近提出的MCT的变体，并具有不同的勘探策略来进行机器人路径计划。我们在模拟的2D和3D环境中进行了7度自由度（DOF）操纵器以及现实世界机器人路径计划任务中的实验评估，证明了MCPP在POMDP任务中的优势。

We present a simple but novel hybrid approach to hyperspectral data cube reconstruction from computed tomography imaging spectrometry (CTIS) images that sequentially combines neural networks and the iterative Expectation Maximization (EM) algorithm. We train and test the ability of the method to reconstruct data cubes of $100\times100\times25$ and $100\times100\times100$ voxels, corresponding to 25 and 100 spectral channels, from simulated CTIS images generated by our CTIS simulator. The hybrid approach utilizes the inherent strength of the Convolutional Neural Network (CNN) with regard to noise and its ability to yield consistent reconstructions and make use of the EM algorithm's ability to generalize to spectral images of any object without training. The hybrid approach achieves better performance than both the CNNs and EM alone for seen (included in CNN training) and unseen (excluded from CNN training) cubes for both the 25- and 100-channel cases. For the 25 spectral channels, the improvements from CNN to the hybrid model (CNN + EM) in terms of the mean-squared errors are between 14-26%. For 100 spectral channels, the improvements between 19-40% are attained with the largest improvement of 40% for the unseen data, to which the CNNs are not exposed during the training.

灵巧的操纵仍然是机器人技术中的一个空缺问题。为了协调研究界为解决这个问题的努力，我们提出了共同的基准。我们设计和构建了机器人平台，该平台托管在MPI上供智能系统托管，可以远程访问。每个平台由三个能够敏捷物体操纵的机器人手指组成。用户能够通过提交自动执行的代码（类似于计算群集）来远程控制平台。使用此设置，i）我们举办机器人竞赛，来自世界任何地方的团队访问我们的平台以应对具有挑战性的任务ii）我们发布了在这些比赛中收集的数据集（包括数百个机器人小时），而我们为研究人员提供了访问自己项目的这些平台。

尽管近期因因果推断领域的进展，迄今为止没有关于从观察数据的收集治疗效应估算的方法。对临床实践的结果是，当缺乏随机试验的结果时，没有指导在真实情景中似乎有效的指导。本文提出了一种务实的方法，以获得从观察性研究的治疗效果的初步但稳健地估算，为前线临床医生提供对其治疗策略的信心程度。我们的研究设计适用于一个公开问题，估算Covid-19密集护理患者的拳击机动的治疗效果。

背景：虽然卷积神经网络（CNN）实现了检测基于磁共振成像（MRI）扫描的阿尔茨海默病（AD）痴呆的高诊断准确性，但它们尚未应用于临床常规。这是一个重要原因是缺乏模型可理解性。最近开发的用于导出CNN相关性图的可视化方法可能有助于填补这种差距。我们调查了具有更高准确性的模型还依赖于先前知识预定义的判别脑区域。方法：我们培训了CNN，用于检测痴呆症和Amnestic认知障碍（MCI）患者的N = 663 T1加权MRI扫描的AD，并通过交叉验证和三个独立样本验证模型的准确性= 1655例。我们评估了相关评分和海马体积的关联，以验证这种方法的临床效用。为了提高模型可理解性，我们实现了3D CNN相关性图的交互式可视化。结果：跨三个独立数据集，组分离表现出广告痴呆症与控制的高精度（AUC $ \ GEQUQ $ 0.92）和MCI与控制的中等精度（AUC $ \约0.75美元）。相关性图表明海马萎缩被认为是广告检测的最具信息性因素，其其他皮质和皮质区域中的萎缩额外贡献。海马内的相关评分与海马体积高度相关（Pearson的r $ \大约$ -0.86，p <0.001）。结论：相关性地图突出了我们假设先验的地区的萎缩。这加强了CNN模型的可理解性，这些模型基于扫描和诊断标签以纯粹的数据驱动方式培训。

We demonstrate a proof-of-concept of a large language model conducting corporate lobbying related activities. We use an autoregressive large language model (OpenAI's text-davinci-003) to determine if proposed U.S. Congressional bills are relevant to specific public companies and provide explanations and confidence levels. For the bills the model deems as relevant, the model drafts a letter to the sponsor of the bill in an attempt to persuade the congressperson to make changes to the proposed legislation. We use hundreds of ground-truth labels of the relevance of a bill to a company to benchmark the performance of the model, which outperforms the baseline of predicting the most common outcome of irrelevance. However, we test the ability to determine the relevance of a bill with the previous OpenAI GPT-3 model (text-davinci-002), which was state-of-the-art on many language tasks until text-davinci-003 was released on November 28, 2022. The performance of text-davinci-002 is worse than simply always predicting that a bill is irrelevant to a company. These results suggest that, as large language models continue to improve core natural language understanding capabilities, performance on corporate lobbying related tasks will continue to improve. We then discuss why this could be problematic for societal-AI alignment.

In the past years, deep learning has seen an increase of usage in the domain of histopathological applications. However, while these approaches have shown great potential, in high-risk environments deep learning models need to be able to judge their own uncertainty and be able to reject inputs when there is a significant chance of misclassification. In this work, we conduct a rigorous evaluation of the most commonly used uncertainty and robustness methods for the classification of Whole-Slide-Images under domain shift using the H\&E stained Camelyon17 breast cancer dataset. Although it is known that histopathological data can be subject to strong domain shift and label noise, to our knowledge this is the first work that compares the most common methods for uncertainty estimation under these aspects. In our experiments, we compare Stochastic Variational Inference, Monte-Carlo Dropout, Deep Ensembles, Test-Time Data Augmentation as well as combinations thereof. We observe that ensembles of methods generally lead to higher accuracies and better calibration and that Test-Time Data Augmentation can be a promising alternative when choosing an appropriate set of augmentations. Across methods, a rejection of the most uncertain tiles leads to a significant increase in classification accuracy on both in-distribution as well as out-of-distribution data. Furthermore, we conduct experiments comparing these methods under varying conditions of label noise. We observe that the border regions of the Camelyon17 dataset are subject to label noise and evaluate the robustness of the included methods against different noise levels. Lastly, we publish our code framework to facilitate further research on uncertainty estimation on histopathological data.

In large-scale machine learning, recent works have studied the effects of compressing gradients in stochastic optimization in order to alleviate the communication bottleneck. These works have collectively revealed that stochastic gradient descent (SGD) is robust to structured perturbations such as quantization, sparsification, and delays. Perhaps surprisingly, despite the surge of interest in large-scale, multi-agent reinforcement learning, almost nothing is known about the analogous question: Are common reinforcement learning (RL) algorithms also robust to similar perturbations? In this paper, we investigate this question by studying a variant of the classical temporal difference (TD) learning algorithm with a perturbed update direction, where a general compression operator is used to model the perturbation. Our main technical contribution is to show that compressed TD algorithms, coupled with an error-feedback mechanism used widely in optimization, exhibit the same non-asymptotic theoretical guarantees as their SGD counterparts. We then extend our results significantly to nonlinear stochastic approximation algorithms and multi-agent settings. In particular, we prove that for multi-agent TD learning, one can achieve linear convergence speedups in the number of agents while communicating just $\tilde{O}(1)$ bits per agent at each time step. Our work is the first to provide finite-time results in RL that account for general compression operators and error-feedback in tandem with linear function approximation and Markovian sampling. Our analysis hinges on studying the drift of a novel Lyapunov function that captures the dynamics of a memory variable introduced by error feedback.

While the capabilities of autonomous systems have been steadily improving in recent years, these systems still struggle to rapidly explore previously unknown environments without the aid of GPS-assisted navigation. The DARPA Subterranean (SubT) Challenge aimed to fast track the development of autonomous exploration systems by evaluating their performance in real-world underground search-and-rescue scenarios. Subterranean environments present a plethora of challenges for robotic systems, such as limited communications, complex topology, visually-degraded sensing, and harsh terrain. The presented solution enables long-term autonomy with minimal human supervision by combining a powerful and independent single-agent autonomy stack, with higher level mission management operating over a flexible mesh network. The autonomy suite deployed on quadruped and wheeled robots was fully independent, freeing the human supervision to loosely supervise the mission and make high-impact strategic decisions. We also discuss lessons learned from fielding our system at the SubT Final Event, relating to vehicle versatility, system adaptability, and re-configurable communications.